Salicylic acid attenuates virulence in endovascular infections by targeting global regulatory pathways in Staphylococcus aureus

Iri Kupferwasser, Leon; R. Yeaman, Michael; C. Nast, Cynthia; Kupferwasser, Deborah; Xiong, Yan-Qiong; Palma, Marco; L. Cheung, Ambrose; S. Bayer, Arnold

doi:10.1172/jci200316876

Public

Salicylic acid attenuates virulence in endovascular infections by targeting global regulatory pathways in Staphylococcus aureus

Published in Journal of Clinical Investigation • Jul 15, 2003

Authors:

Leon Iri Kupferwasser

Michael R. Yeaman

Cynthia C. Nast

Abstract

Aspirin has been previously shown to reduce the in vivo virulence of Staphylococcus aureus in experimental endocarditis, through antiplatelet and antimicrobial mechanisms. In the present study, salicylic acid, the major in vivo metabolite of aspirin, mitigated two important virulence phenotypes in b...

Subject

Regulon

Microbiology

Virulence

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