Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer

Boucharaba, Ahmed; Serre, Claire‐Marie; Grès, Sandra; Sébastien Saulnier‐Blache, Jean; Bordet, Jean‐Claude; Guglielmi, Julien; Clézardin, Philippe; Peyruchaud, Olivier

doi:10.1172/jci200422123

Public

Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer

Published in Journal of Clinical Investigation • Dec 15, 2004

Authors:

Ahmed Boucharaba

Claire‐Marie Serre

Sandra Grès

Abstract

The role of lysophosphatidic acid (LPA) in cancer is poorly understood. Here we provide evidence for a role of LPA in the progression of breast cancer bone metastases. LPA receptors LPA(1), LPA(2), and LPA(3) were expressed in human primary breast tumors and a series of human breast cancer cell line...

Subject

Lysophosphatidic acid

Cancer research

Bone resorption

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