Fasting Insulin and Outcome in Early-Stage Breast Cancer: Results of a Prospective Cohort Study

J. Goodwin, Pamela; Ennis, Marguerite; I. Pritchard, Kathleen; Trudeau, Maureen; Koo, Jarley; Madarnas, Yolanda; Hartwick, Warren; Hoffman, Barry; Hood, Nicky

doi:10.1200/jco.2002.20.1.42

Public

Fasting Insulin and Outcome in Early-Stage Breast Cancer: Results of a Prospective Cohort Study

Published in Journal of Clinical Oncology • Jan 1, 2002

Authors:

Pamela J. Goodwin

Marguerite Ennis

Kathleen I. Pritchard

Abstract

PURPOSE: Insulin, a member of a family of growth factors that includes insulin-like growth factor (IGF)-I and IGF-II, exerts mitogenic effects on normal and malignant breast epithelial cells, acting via insulin and IGF-I receptors. Because of this and because of its recognized association with obesi...

Subject

Medicine

Breast cancer

Hazard ratio

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