CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation

Ma, Weilie; Bryce, Paul; A. Humbles, Alison; Laouini, Dhafer; Yalçindağ, Ali; Alenius, Harri; S. Friend, Daniel; C. Oettgen, Hans; Gérard, Craig; S. Geha, Raif

doi:10.1172/jci0214097

Public

CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation

Shared by NobleBlocks on Mar 1, 2002 • 12:00 AM UTC

Authors:

Weilie Ma

Paul Bryce

Alison A. Humbles

Abstract

The CC chemokine receptor 3 (CCR3) is expressed by eosinophils, mast cells, and Th2 cells.We used CCR3 -/-mice to assess the role of CCR3 in a murine model of allergic skin inflammation induced by repeated epicutaneous sensitization with ovalbumin (OVA), and characterized by eosinophil skin infiltra...

Subject

Eosinophilia

Airway hyperresponsiveness

Immunology

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