Impact of Deuteration on the Assembly Kinetics of Transthyretin Monitored by Native Mass Spectrometry and Implications for Amyloidoses

Yee, A.W.; Moulin, Martine; Breteau, Nina; Haertlein, Michael; P. Mitchell, Edward; Cooper, J.B.; Boeri Erba, Elisabetta; Trevor Forsyth, V.

doi:10.1002/ange.201602747

Public

Impact of Deuteration on the Assembly Kinetics of Transthyretin Monitored by Native Mass Spectrometry and Implications for Amyloidoses

Published in Angewandte Chemie • Jun 17, 2016

Authors:

A.W. Yee

Martine Moulin

Nina Breteau

Abstract

Abstract It is well established that the formation of transthyretin (TTR) amyloid fibrils is linked to the destabilization and dissociation of its tetrameric structure into insoluble aggregates. Isotope labeling is used for the study of TTR by NMR, neutron diffraction, and mass spectrometry (MS). He...

Subject

Transthyretin

Chemistry

Hydrogen–deuterium exchange

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!