Pyogenic Bacterial Infections in Humans with IRAK-4 Deficiency

Pïcard, Capucine; Puel, Anne; Bonnet, Marion; Ku, Cheng‐Lung; Bustamante, Jacinta; Yang, Kun; Soudais, Claire; Boisson‐Dupuis, Stéphanie; Feinberg, Jacqueline; Fieschi, Claire; Elbim, Carole; Hitchcock, Remi; A. Lammas, David; Davies, Graham; Al‐Ghonaium, Abdulaziz; Al-Rayes, Hassan; Aljumaah, Suliman; Al-Hajjar, Sami; Al-Mohsen, Ibrahim; H. Frayha, Husn; P. Rucker, Rajivi; R. Hawn, Thomas; Aderem, Alan; Tufenkeji, Haysam; Haraguchi, Soichi; K. Day, Noorbibi; A. Good, Robert; Gougerot‐Pocidalo, Marie‐Anne; Ozinsky, Adrian; Casanova, Jean‐Laurent

doi:10.1126/science.1081902

Public

Pyogenic Bacterial Infections in Humans with IRAK-4 Deficiency

Published in Science • Mar 27, 2003

Authors:

Capucine Pïcard

Anne Puel

Marion Bonnet

Abstract

Members of the Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) superfamily share an intracytoplasmic Toll-IL-1 receptor (TIR) domain, which mediates recruitment of the interleukin-1 receptor-associated kinase (IRAK) complex via TIR-containing adapter molecules. We describe three unrelate...

Subject

Receptor

Biology

Signal transduction

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