A multimodal cell census and atlas of the mammalian primary motor cortex

Initiative Cell Census Network (BICCN), BRAIN; Initiative Cell Census Network (BICCN) Corresponding authors, BRAIN; M. Callaway, Edward; Dong, Hong‐Wei; R. Ecker, Joseph; Hawrylycz, Michael; Josh Huang, Z.; S. Lein, Ed; Ngai, John; Osten, Pavel; Ren, Bing; S. Tolias, Andreas; White, Owen; Zeng, Hongkui; Zhuang, Xiaowei; contributing principal investigators, BICCN; A. Ascoli, Giorgio; Margarita Behrens, M.; Chun, Jerold; Feng, Guoping; C. Gee, James; Ghosh, Satrajit; O. Halchenko, Yaroslav; Hertzano, Ronna; Kook Lim, Byung; E. Martone, Maryann; Ng, Lydia; Pachter, Lior; J. Ropelewski, Alexander; L. Tickle, Timothy; William Yang, X.; Zhang, Kun; manuscript editors, Principal; writing and figure generation, Manuscript; E. Bakken, Trygve; Berens, Philipp; L. Daigle, Tanya; A. Harris, Julie; L. Jorstad, Nikolas; Kalmbach, Brian; Kobak, Dmitry; Eric Li, Yang; Liu, Hanqing; S. Matho, Katherine; A. Mukamel, Eran; Naeemi, Maitham; Scala, Federico; Tan, Pengcheng; T. Ting, Jonathan; Xie, Fangming; Zhang, Meng; Zhang, Zhuzhu; Zhou, Jingtian; Zingg, Brian; coordination, Analysis; data analysis, Integrated; J. Armand, Ethan; Yao, Zizhen; and snRNA-seq data generation and processing, scRNA-seq; Bertagnolli, Darren; Casper, Tamara; Crichton, Kirsten; Dee, Nick; Diep, Dinh; Ding, Song‐Lin; Dong, Weixiu; L. Dougherty, Elizabeth; Fong, Olivia; Goldman, Melissa; Goldy, Jeff; D. Hodge, Rebecca; Hu, Lijuan; Dirk Keene, C.; M. Krienen, Fenna; Kroll, Matthew; B. Lake, Blue; Lathia, Kanan; Linnarsson, Sten; S. Liu, Christine; Z. Macosko, Evan; A. McCarroll, Steven; McMillen, Delissa; Nadaf, Naeem; Nghi Nguyen, Thuc; R. Palmer, Carter; Pham, Thanh; Plongthongkum, Nongluk; Reed, Nora; Regev, Aviv; Rimorin, Christine; J. Romanow, William; Savoia, Stephen; Siletti, Kimberly; A. Smith, Kimberly; Šulc, Josef; Tasic, Bosiljka; Tieu, Michael; Torkelson, Amy; Tung, Herman; T. J. van Velthoven, Cindy; Vanderburg, Charles; Marie Yanny, Anna; data generation and processing, ATAC-seq; Fang, Rongxin; Hou, Xiaomeng; Lucero, Jacinta; Osteen, Julia; Pinto‐Duarte, António; Poirion, Olivier; Preißl, Sebastian; Wang, Xinxin; data production and analysis, Methylcytosine; Aldridge, Andrew; Bartlett, Anna; Boggeman, Lara; O’Connor, Carolyn; Castanon, Rosa; Chen, Huaming; Fitzpatrick, Conor; Luo, Chongyuan; R. Nery, Joseph; Nunn, Michael; Rivkin, Angeline; Tian, Wei; data generation and processing, Epi-retro-seq; Dominguez, Bertha; Ito-Cole, Tony; W. Jacobs, Matthew; Jin, Xin; Lee, Cheng-Ta; Lee, Kuo‐Fen; Assakura Miyazaki, Paula; Pang, Yan; Rashid, Mohammad; B. Smith, Jared; Vu, Minh; Williams, Elora; data analysis, ‘Omics; Biancalani, Tommaso; Sina Booeshaghi, A.; Crow, Megan; Dudoit, Sandrine; Fischer, Stephan; Gillis, Jesse; Hu, Qiwen; V. Kharchenko, Peter; Niu, Sheng-Yong; Ntranos, Vasilis; Purdom, Elizabeth; Risso, Davide; Roux de Bézieux, Hector; Somasundaram, Saroja; Street, Kelly; Svensson, Valentine; Dhaval Vaishnav, Eeshit; Van Den Berge, Koen; D. Welch, Joshua; and connectivity data generation, Tracing; An, Xu; S. Bateup, Helen; Bowman, Ian; K. Chance, Rebecca; N. Foster, Nicholas; Galbavy, William; Gong, Hui; Gou, Lin; Hatfield, Joshua; Hintiryan, Houri; E. Hirokawa, Karla; Kim, Gukhan; J. Kramer, Daniel; Li, Anan; Li, Xiangning; Luo, Qingming; Muñoz-Castañeda, Rodrigo; Stafford, David; data generation and reconstruction, Morphology; Feng, Zhao; Jia, Xueyan; Jiang, Shengdian; Jiang, Tao; Kuang, Xiuli; Larsen, Rachael; Lesnar, Phil; Li, Yaoyao; Li, Yuanyuan; Liu, Lijuan; Peng, Hanchuan; Qu, Lei; Ren, Miao; Ruan, Zongcai; Shen, Elise; Song, Yuanyuan; Wakeman, Wayne; Wang, Peng; Wang, Yimin; Wang, Yun; Yin, Lulu; Yuan, Jing; Zhao, Sujun; Zhao, Xuan; and other data generation, OLST/STPT; Narasimhan, Arun; Palaniswamy, Ramesh; connectivity and imaging analysis, Morphology,; Banerjee, Samik; Ding, Liya; Huilgol, Dhananjay; Huo, Bing‐Xing; Kuo, Hsien-Chi; Laturnus, Sophie; Li, Xu; P. Mitra, Partha; Mizrachi, Judith; Wang, Quanxin; Xie, Peng; Xiong, Feng; Yu, Yang; resolved single-cell transcriptomics (MERFISH), Spatially; W. Eichhorn, Stephen; profiling (Patch-seq), Multimodal; Berg, Jim; Bernabucci, Matteo; Bernaerts, Yves; R. Cadwell, Cathryn; Ramon Castro, Jesus; Dalley, Rachel; Hartmanis, Leonard; D. Horwitz, Gregory; Jiang, Xiaolong; L. Ko, Andrew; Miranda, Elanine; Mulherkar, Shalaka; R. Nicovich, Philip; F. Owen, Scott; Sandberg, Rickard; A. Sorensen, Staci; Huan Tan, Zheng; tools, Transgenic; W. Allen, Shona; Hockemeyer, Dirk; Y. Lee, Angus; B. Veldman, Matthew; archive and analytics, NeMO; S. Adkins, Ricky; A. Ament, Seth; Corrada Bravo, Héctor; Carter, Robert; Chatterjee, Apaala; Colantuoni, Carlo; Crabtree, Jonathan; H. Creasy, Heather; Felix, Victor; Giglio, Michelle; R. Herb, Brian; Kancherla, Jayaram; Mahurkar, Anup; McCracken, Carrie; Nickel, Lance; Olley, Dustin; Orvis, Joshua; Schor, Michael; Hood, Greg; archive, DANDI; Dichter, Ben; Grauer, Michael; Helba, Brian; Bandrowski, Anita; Barkas, Nikolaos; Carlin, Benjamin; D. D’Orazi, Florence; Degatano, Kylee; Gillespie, Tom; Khajouei, Farzaneh; M. Konwar, Kishori; L. Thompson, Carol; management, Project; Kelly, Kathleen; Mok, Stephanie; M. Sunkin, Susan

doi:10.1038/s41586-021-03950-0

Public

A multimodal cell census and atlas of the mammalian primary motor cortex

Published in Nature • Oct 6, 2021

Authors:

BRAIN Initiative Cell Census Network (BICCN)

BRAIN Initiative Cell Census Network (BICCN) Corresponding authors

Edward M. Callaway

Abstract

Abstract Here we report the generation of a multimodal cell census and atlas of the mammalian primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network (BICCN). This was achieved by coordinated large-scale analyses of single-cell transcriptomes, chromatin accessibility,...

Subject

Atlas (anatomy)

Primary motor cortex

Census

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