A Versatile and Scalable Two-Step Ion-Exchange Chromatography Process for the Purification of Recombinant Adeno-associated Virus Serotypes-2 and -5

Brument, Nicole; Morenweiser, Robert; Blouin, Véronique; Toublanc, Estelle; Raimbaud, Isabelle; Cherel, Yann; Folliot, Sébastien; Gaden, Florence; BOULANGER, P; KRONERLUX, G

doi:10.1016/s1525-0016(02)90719-7

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A Versatile and Scalable Two-Step Ion-Exchange Chromatography Process for the Purification of Recombinant Adeno-associated Virus Serotypes-2 and -5

Shared by NobleBlocks on Oct 28, 2002 • 12:00 AM UTC

Authors:

Nicole Brument

Robert Morenweiser

Véronique Blouin

Abstract

Here we describe the development of a two-step chromatography process based on the use of ion-exchange resins for the purification of recombinant adeno-associated virus (rAAV) serotypes-2 and -5. In vitro and in vivo results demonstrate that this method, which does not require any prepurification st...

Subject

Recombinant DNA

Adeno-associated virus

Ion chromatography

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