CCR2 modulates inflammatory and metabolic effects of high-fat feeding

P. Weisberg, Stuart; Hunter, Deborah; Huber, Reid; E. Lemieux, Jacob; Slaymaker, Sarah; Vaddi, Kris; Charo, Israel; L. Leibel, Rudolph; W. Ferrante, Anthony

doi:10.1172/jci24335

Public

CCR2 modulates inflammatory and metabolic effects of high-fat feeding

Published in Journal of Clinical Investigation • Dec 8, 2005

Authors:

Stuart P. Weisberg

Deborah Hunter

Reid Huber

Abstract

The C-C motif chemokine receptor-2 (CCR2) regulates monocyte and macrophage recruitment and is necessary for macrophage-dependent inflammatory responses and the development of atherosclerosis. Although adipose tissue expression and circulating concentrations of CCL2 (also known as MCP1), a high-affi...

Subject

Insulin resistance

Adipose tissue

CCR2

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