Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients

Worlitzsch, Dieter; Tarran, Robert; Ulrich, Martina; Schwab, Ute; Cekici, Aynur; C. Meyer, Keith; Birrer, P.; Bellon, G.; Berger, Jürgen; Weiß, Tilo; Botzenhart, K; R. Yankaskas, James; H. Randell, Scott; C. Boucher, Richard; Döring, Gerd

doi:10.1172/jci0213870

Public

Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients

Published in Journal of Clinical Investigation • Feb 1, 2002

Authors:

Dieter Worlitzsch

Robert Tarran

Martina Ulrich

Abstract

Current theories of CF pathogenesis predict different predisposing "local environmental" conditions and sites of bacterial infection within CF airways.Here we show that, in CF patients with established lung disease, Psuedomonas aeruginosa was located within hypoxic mucopurulent masses in airway lume...

Subject

Cystic fibrosis

Mucus

Pseudomonas aeruginosa

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