Axonal degeneration in paraplegin-deficient mice is associated with abnormal mitochondria and impairment of axonal transport

In several neurodegenerative diseases, axonal degeneration occurs before neuronal death and contributes significantly to patients’ disability. Hereditary spastic paraplegia (HSP) is a genetically heterogeneous condition characterized by selective degeneration of axons of the corticospinal tracts and... View More