LncRNA RPPH1 promotes colorectal cancer metastasis by interacting with TUBB3 and by promoting exosomes-mediated macrophage M2 polarization

Liang, Zhenxing; Liu, Huashan; Wang, Fengwei; Xiong, Li; Zhou, Chi; Hu, Tuo; He, Xiaowen; Wu, Xiaojian; Wu, Xiao-jian; Xie, Dan; Wu, Xian-rui; Wu, Xianrui; Lan, Ping

doi:10.1038/s41419-019-2077-0

Public

LncRNA RPPH1 promotes colorectal cancer metastasis by interacting with TUBB3 and by promoting exosomes-mediated macrophage M2 polarization

Published in Cell Death and Disease • Nov 4, 2019

Authors:

Zhenxing Liang

Huashan Liu

Fengwei Wang

Abstract

Metastasis is a well-known poor prognostic factor in cancer. However, the mechanisms how long non-coding RNAs (lncRNAs) regulate metastasis in colorectal cancer (CRC) remain largely unknown. Besides, tumor-associated macrophages (TAMs) play an important role in tumor progression, yet the contributio...

Subject

Microvesicles

Macrophage polarization

Colorectal cancer

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!