Prognostic Significance of Autoimmunity during Treatment of Melanoma with Interferon

Gogas, Helen; Ioannovich, J.; Dafni, Urania; Stavropoulou-Giokas, Catherine; Frangia, Konstantina; Tsoutsos, Dimosthenis; Panagiotou, P.; Polyzos, Aristidis; Papadopoulos, O.; Stratigos, Alexandros; Markopoulos, Christos; Bafaloukos, Dimitrios; Pectasides, Dimitrios; Fountzilas, George; M. Kirkwood, John

doi:10.1056/nejmoa053007

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Prognostic Significance of Autoimmunity during Treatment of Melanoma with Interferon

Published in New England Journal of Medicine • Feb 15, 2006

Authors:

Helen Gogas

J. Ioannovich

Urania Dafni

Abstract

BACKGROUND: Immunotherapy for advanced melanoma induces serologic and clinical manifestations of autoimmunity. We assessed the prognostic significance of autoimmunity in patients with stage IIB, IIC, or III melanoma who were treated with high-dose adjuvant interferon alfa-2b. METHODS: We enrolled 20...

Subject

Medicine

Autoimmunity

Melanoma

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