Therapeutic targeting of LCK tyrosine kinase and mTOR signaling in T-cell acute lymphoblastic leukemia

Laukkanen, Saara; Veloso, Alexandra; Yan, Chuan; Oksa, Laura; Alpert, Eric; Do, Daniel; Hyvärinen, Noora; M. McCarthy, Karin; Adhikari, Abhinav; Yang, Qiqi; Iyer, Sowmya; P. Garcia, Sara; Pello, Annukka; Ruokoranta, Tanja; Moisio, Sanni; Adhikari, Sadiksha; A. Yoder, Jeffrey; Gallagher, Kayleigh; Whelton, Lauren; Allen, James; Jin, Alexander; Loontiens, Siebe; Heinäniemi, Merja; A. Kelliher, Michelle; A. Heckman, Caroline; Lohi, Olli; M. Langenau, David

doi:10.1182/blood.2021015106

Public

Therapeutic targeting of LCK tyrosine kinase and mTOR signaling in T-cell acute lymphoblastic leukemia

Published in Blood • May 11, 2022

Authors:

Saara Laukkanen

Alexandra Veloso

Chuan Yan

Abstract

Relapse and refractory T-cell acute lymphoblastic leukemia (T-ALL) has a poor prognosis, and new combination therapies are sorely needed. Here, we used an ex vivo high-throughput screening platform to identify drug combinations that kill zebrafish T-ALL and then validated top drug combinations for p...

Subject

Dasatinib

mTORC1

Cancer research

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