Transfusing Convalescent Plasma as Post-Exposure Prophylaxis Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Double-Blinded, Phase 2 Randomized, Controlled Trial

Shoham, Shmuel; M. Bloch, Evan; Casadevall, Arturo; F. Hanley, Daniel; Lau, Bryan; A. Gebo, Kelly; R. Cachay, Edward; Kassaye, Seble; H. Paxton, James; M. Gerber, Jonathan; C. Levine, Adam; Naeim, Arash; S. Currier, Judith; Patel, Bela; S. Allen, Elizabeth; Anjan, Shweta; J. Appel, Lawrence; Baksh, Sheriza; W. Blair, Paul; Bowen, Anthony; Broderick, Patrick; Caputo, Christopher; Cluzet, Valerie; Elena Cordisco, Marie; Cruser, Daniel; Ehrhardt, Stephan; N. Forthal, Donald; Fukuta, Yuriko; L. Gawad, Amy; J. Gniadek, Thomas; Hammel, Jean; A. Huamán, Moisés; A. Jabs, Douglas; Jedlicka, Anne; Karlen, Nicky; L. Klein, Sabra; Laeyendecker, Oliver; Lane, Karen; McBee, Nichol; Meisenberg, Barry; A. Merlo, Christian; Mosnaim, Giselle; Park, Han-Sol; Pekosz, Andrew; Petrini, Joann; Rausch, William; Shade, David; R. Shapiro, Janna; Singleton, Jo; G. Sutcliffe, Catherine; L. Thomas, David; Yarava, Anusha; S. Zand, Martin; M. Zenilman, Jonathan; A.R. Tobian, Aaron; Sullivan, David

doi:10.1093/cid/ciac372

Public

Transfusing Convalescent Plasma as Post-Exposure Prophylaxis Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Double-Blinded, Phase 2 Randomized, Controlled Trial

Published in Clinical Infectious Diseases • May 17, 2022

Authors:

Shmuel Shoham

Evan M. Bloch

Arturo Casadevall

Abstract

BACKGROUND: The efficacy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) convalescent plasma (CCP) for preventing infection in exposed, uninfected individuals is unknown. CCP might prevent infection when administered before symptoms or laboratory evidence of infection. METHODS: This ...

Subject

Medicine

Asymptomatic

Randomized controlled trial

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