Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice

Belouzard, Sandrine; Machelart, Arnaud; Sencio, Valentin; Vausselin, Thibaut; Hoffmann, Eik; Deboosère, Nathalie; Rouillé, Yves; Desmarets, Lowiese; Séron, Karin; Danneels, Adeline; Robil, Cyril; Belloy, Loïc; Moreau, Camille; Piveteau, Catherine; Biela, Alexandre; Vandeputte, Alexandre; Heumel, Séverine; Deruyter, Lucie; Dumont, Julie; Leroux, Florence; Engelmann, Ilka; Kazali Alidjinou, Enagnon; Hober, Didier; Brodin, Priscille; Beghyn, Terence; Trottein, François; Déprez, Benoît; Dubuisson, Jean

doi:10.1371/journal.ppat.1010498

Public

Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice

Published in PLoS Pathogens • May 19, 2022

Authors:

Sandrine Belouzard

Arnaud Machelart

Valentin Sencio

Abstract

Drug repurposing has the advantage of shortening regulatory preclinical development steps. Here, we screened a library of drug compounds, already registered in one or several geographical areas, to identify those exhibiting antiviral activity against SARS-CoV-2 with relevant potency. Of the 1,942 co...

Subject

Vero cell

Drug repositioning

Potency

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