Ultrasound-facilitated, catheter-directed thrombolysis vs anticoagulation alone for acute intermediate-high-risk pulmonary embolism: Rationale and design of the HI-PEITHO study

A. Klok, Frederikus; Piazza, Gregory; Sharp, Andrew; Ní Áinle, Fionnuala; R. Jaff, Michael; Chauhan, Nikhil; Patel, Binal; Barco, Stefano; Z. Goldhaber, Samuel; Kucher, Nils; Lang, Iréne; Schmidtmann, Irene; M. Sterling, Keith; Becker, Dorothea; Martin, Nadine; Rosenfield, Kenneth; Konstantinides, Stavros

doi:10.1016/j.ahj.2022.05.011

Public

Ultrasound-facilitated, catheter-directed thrombolysis vs anticoagulation alone for acute intermediate-high-risk pulmonary embolism: Rationale and design of the HI-PEITHO study

Published in American Heart Journal • May 16, 2022

Authors:

Frederikus A. Klok

Gregory Piazza

Andrew Sharp

Abstract

BACKGROUND: Due to the bleeding risk of full-dose systemic thrombolysis and the lack of major trials focusing on the clinical benefits of catheter-directed treatment, heparin antiocoagulation remains the standard of care for patients with intermediate-high-risk pulmonary embolism (PE). METHODS AND R...

Subject

Medicine

Thrombolysis

Pulmonary embolism

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