Mapping the developing human immune system across organs

Suo, Chenqu; Dann, Emma; Goh, Issac; Jardine, Laura; Kleshchevnikov, Vitalii; Park, Jong-Eun; A. Botting, Rachel; Stephenson, Emily; Engelbert, Justin; Kelvin Tuong, Zewen; Polański, Krzysztof; Yayon, Nadav; Xu, Chuan; Suchánek, Ondřej; Elmentaite, Rasa; Domínguez Conde, Cecilia; He, Peng; Pritchard, Sophie; Miah, Mohi; Moldovan, Corina; S. Steemers, Alexander; Mazin, Pavel; Prete, Martin; Horsfall, Dave; C. Marioni, John; R. Clatworthy, Menna; Haniffa, Muzlifah; A. Teichmann, Sarah

doi:10.1126/science.abo0510

Public

Mapping the developing human immune system across organs

Published in Science • May 12, 2022

Authors:

Chenqu Suo

Emma Dann

Issac Goh

Abstract

Single-cell genomics studies have decoded the immune cell composition of several human prenatal organs but were limited in describing the developing immune system as a distributed network across tissues. We profiled nine prenatal tissues combining single-cell RNA sequencing, antigen-receptor sequenc...

Subject

Immune system

Biology

Myeloid

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