Cross-tissue immune cell analysis reveals tissue-specific features in humans

Domínguez Conde, Cecilia; Xu, Chuan; B. Jarvis, Lorna; B. Rainbow, Daniel; B. Wells, Steven; Gomes, Tomás; K. Howlett, S.; Suchánek, Ondřej; Polański, Krzysztof; W. King, Hamish; Mamanova, Lira; Huang, Ni; A. Szabo, Peter; Richardson, Laura; Bolt, Liam; S. Fasouli, Eirini; T. Mahbubani, Krishnaa; Prete, Martin; Tuck, Elizabeth; Richoz, Nathan; Kelvin Tuong, Zewen; Campos, LS; S. Mousa, Hani; Needham, Edward; Pritchard, Sophie; Li, Tong; Elmentaite, Rasa; Park, Jong-Eun; Rahmani, Elior; Chen, David; Menon, David; Ali Bayraktar, Omer; K. James, Louisa; B. Meyer, Kerstin; Yosef, Nir; R. Clatworthy, Menna; A. Sims, Peter; L. Färber, Donna; Saeb‐Parsy, Kourosh; Jones, Joanne; A. Teichmann, Sarah

doi:10.1126/science.abl5197

Public

Cross-tissue immune cell analysis reveals tissue-specific features in humans

Published in Science • May 12, 2022

Authors:

Cecilia Domínguez Conde

Chuan Xu

Lorna B. Jarvis

Abstract

Despite their crucial role in health and disease, our knowledge of immune cells within human tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 adult donors by single-cell RNA sequencing and VDJ sequencing generating a dataset of ~360,000 cells. To systematically resol...

Subject

Immune system

Biology

Cell type

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