Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells

Pan, Lianhong; Feng, Fan; Wu, Jiaqin; Fan, Shibing; Han, Juanjuan; Wang, Shunxi; Yang, Li; Liu, Wanqian; Wang, Chunli; Xu, Kang

doi:10.1016/j.phrs.2022.106270

Public

Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells

Published in Pharmacological Research • May 21, 2022

Authors:

Lianhong Pan

Fan Feng

Jiaqin Wu

Abstract

Cancer stem cells drive tumor initiation, progression, and recurrence, which compromise the effectiveness of anti-tumor drugs. Here, we report that demethylzeylasteral (DML), a triterpene anti-tumor compound, suppressed tumorigenesis of liver cancer stem cells (LCSCs) by interfering with lactylation...

Subject

Carcinogenesis

Cancer research

Histone

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