Defective mitophagy in aged macrophages promotes mitochondrial DNA cytosolic leakage to activate STING signaling during liver sterile inflammation

Zhong, Weizhe; Rao, Zhuqing; Xu, Jian; Sun, Yu; Hu, Haoran; Wang, Ping; Xia, Yongxiang; Pan, Xiongxiong; Tang, Weiwei; Chen, Ziyi; Zhou, Haoming; Wang, Xuehao

doi:10.1111/acel.13622

Public

Defective mitophagy in aged macrophages promotes mitochondrial DNA cytosolic leakage to activate STING signaling during liver sterile inflammation

Published in Aging Cell • May 22, 2022

Authors:

Weizhe Zhong

Zhuqing Rao

Jian Xu

Abstract

Macrophage-stimulator of interferon genes (STING) signaling mediated sterile inflammation has been implicated in various age-related diseases. However, whether and how macrophage mitochondrial DNA (mtDNA) regulates STING signaling in aged macrophages remains largely unknown. We found that hypoxia-re...

Subject

Mitophagy

Cell biology

Biology

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