Defective mitophagy in aged macrophages promotes mitochondrial DNA cytosolic leakage to activate STING signaling during liver sterile inflammation

Zhong, Weizhe; Rao, Zhuqing; Xu, Jian; Sun, Yu; Hu, Haoran; Wang, Ping; Xia, Yongxiang; Pan, Xiongxiong; Tang, Weiwei; Chen, Ziyi; Zhou, Haoming; Wang, Xuehao

doi:10.1111/acel.13622

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Defective mitophagy in aged macrophages promotes mitochondrial DNA cytosolic leakage to activate STING signaling during liver sterile inflammation

Shared by NobleBlocks on May 22, 2022 • 12:00 AM UTC

Authors:

Weizhe Zhong

Zhuqing Rao

Jian Xu

Abstract

Abstract Macrophage‐stimulator of interferon genes (STING) signaling mediated sterile inflammation has been implicated in various age‐related diseases. However, whether and how macrophage mitochondrial DNA (mtDNA) regulates STING signaling in aged macrophages remains largely unknown. We found that h...

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