Second Revision of the International Staging System (R2-ISS) for Overall Survival in Multiple Myeloma: A European Myeloma Network (EMN) Report Within the HARMONY Project

D’Agostino, Mattia; A. Cairns, David; José Lahuerta, Juan; Wester, Ruth; Bertsch, Uta; Waage, Anders; Zamagni, Elena; Mateos, María‐Victoria; Dall’Olio, Daniele; W.C.J. van de Donk, Niels; Jackson, Graham; Rocchi, Serena; Salwender, Hans; Bladé Creixenti, Joan; van der Holt, Bronno; Castellani, Gastone; Bonello, Francesca; Capra, Andréa; Elias, K.; Dürig, Jan; Gay, Francesca; Zweegman, Sonja; Cavo, Michèle; Kaiser, Martin; Goldschmidt, Hartmut; María Hernández‐Rivas, Jesús; Larocca, Alessandra; Cook, Gordon; F. San Miguel, Jesús; Boccadoro, Mario; Sonneveld, Pieter

doi:10.1200/jco.21.02614

Public

Second Revision of the International Staging System (R2-ISS) for Overall Survival in Multiple Myeloma: A European Myeloma Network (EMN) Report Within the HARMONY Project

Published in Journal of Clinical Oncology • May 23, 2022

Authors:

Mattia D’Agostino

David A. Cairns

Juan José Lahuerta

Abstract

PURPOSE: Patients with newly diagnosed multiple myeloma (NDMM) show heterogeneous outcomes, and approximately 60% of them are at intermediate-risk according to the Revised International Staging system (R-ISS), the standard-of-care risk stratification model. Moreover, chromosome 1q gain/amplification...

Subject

Medicine

Multiple myeloma

Internal medicine

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