ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity

Fougerat, Anne; Schoiswohl, Gabriele; Polizzi, Arnaud; Régnier, Marion; Wagner, Carina; Smati, Sarra; Fougeray, Tiffany; Lippi, Yannick; Lasserre, Frédèric; Raho, Ilyès; Melin, Valentine; Tramunt, Blandine; Métivier, Raphaël; Sommer, Caroline; Benhamed, Fadila; Alkhoury, Chantal; Greulich, Franziska; Jouffe, Céline; Emile, Anthony; Schupp, Michael; Gourdy, Pierre; Dubot, Patricia; Levade, Thierry; Meynard, Delphine; Ellero‐Simatos, Sandrine; Gamet‐Payrastre, Laurence; Panasyuk, Ganna; Henriette Uhlenhaut, N.; Amri, Ez‐Zoubir; Cruciani‐Guglielmacci, Céline; Postic, Catherine; Wahli, Walter; Loiseau, Nicolas; Montagner, Alexandra; Langin, Dominique; Lass, Achim; Guillou, Hervé

doi:10.1016/j.celrep.2022.110910

Public

ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity

Published in Cell Reports • Jun 1, 2022

Authors:

Anne Fougerat

Gabriele Schoiswohl

Arnaud Polizzi

Abstract

In hepatocytes, peroxisome proliferator-activated receptor α (PPARα) orchestrates a genomic and metabolic response required for homeostasis during fasting. This includes the biosynthesis of ketone bodies and of fibroblast growth factor 21 (FGF21). Here we show that in the absence of adipose triglyce...

Subject

Lipolysis

Adipose tissue

White adipose tissue

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