Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer

Tie, Jeanne; D. Cohen, Joshua; Lahouel, Kamel; Lo, Serigne; Wang, Yuxuan; Kosmider, Suzanne; Wong, Rachel; Shapiro, Jeremy; Lee, Margaret; Harris, Sam; Khattak, Adnan; Burge, Matthew; Harris, Marion; Lynam, James; Nott, Louise; Day, Fiona; Hayes, Theresa; McLachlan, Sue‐Anne; Lee, Belinda; Ptak, Janine; Silliman, Natalie; Dobbyn, Lisa; Popoli, Maria; H. Hruban, Ralph; Marie Lennon, Anne; Papadopoulos, Nicholas; W. Kinzler, Kenneth; Vogelstein, Bert; Tomasetti, Cristian; Gibbs, Peter

doi:10.1056/nejmoa2200075

Public

Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer

Published in New England Journal of Medicine • Jun 4, 2022

Authors:

Jeanne Tie

Joshua D. Cohen

Kamel Lahouel

Abstract

BACKGROUND: The role of adjuvant chemotherapy in stage II colon cancer continues to be debated. The presence of circulating tumor DNA (ctDNA) after surgery predicts very poor recurrence-free survival, whereas its absence predicts a low risk of recurrence. The benefit of adjuvant chemotherapy for ctD...

Subject

Colorectal cancer

Medicine

Oncology

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