LPCAT3 Inhibitors Remodel the Polyunsaturated Phospholipid Content of Human Cells and Protect from Ferroptosis

Reed, Alex; Ichu, Taka-Aki; Milosevich, Natalia; Melillo, Bruno; A. Schafroth, Michael; Otsuka, Yuka; Scampavia, Louis; Spicer, Timothy; F. Cravatt, Benjamin

doi:10.1021/acschembio.2c00317

Public

LPCAT3 Inhibitors Remodel the Polyunsaturated Phospholipid Content of Human Cells and Protect from Ferroptosis

Published in ACS Chemical Biology • Jun 6, 2022

Authors:

Alex Reed

Taka-Aki Ichu

Natalia Milosevich

Abstract

LPCAT3 is an integral membrane acyltransferase in the Lands cycle responsible for generating C20:4 phospholipids and has been implicated in key biological processes such as intestinal lipid absorption, lipoprotein assembly, and ferroptosis. Small-molecule inhibitors of LPCAT3 have not yet been descr...

Subject

Phospholipid

Biology

Biochemistry

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