METTL3 Inhibits Antitumor Immunity by Targeting m<sup>6</sup>A-BHLHE41-CXCL1/CXCR2 Axis to Promote Colorectal Cancer.

H, Chen; Y, Pan; Q, Zhou; C, Liang; CC, Wong; Y, Zhou; D, Huang; W, Liu; J, Zhai; H, Gou; H, Su; X, Zhang; H, Xu; Y, Wang; W, Kang; Wu WK, Kei; J, Yu

doi:10.1053/j.gastro.2022.06.024

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METTL3 Inhibits Antitumor Immunity by Targeting m6A-BHLHE41-CXCL1/CXCR2 Axis to Promote Colorectal Cancer.

Shared by NobleBlocks on Jun 11, 2022 • 12:00 AM UTC

Authors:

Chen H

Pan Y

Zhou Q

Abstract

Background & aims N6-Methyladenosine (m6A) is the most prevalent RNA modification and recognized as an important epitranscriptomic mechanism in colorectal cancer (CRC). We aimed to exploit whether and how tumor-intrinsic m6A modification driven by methyltransferase like 3 (METTL3) can dictate the im...

Subject

Immunotherapy

Colorectal Cancer

Mdsc

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