Glioma progression is shaped by genetic evolution and microenvironment interactions

S. Varn, Frederick; C. Johnson, Kevin; Martinek, Jan; T. Huse, Jason; P. Nasrallah, MacLean; Wesseling, Pieter; Cooper, Lee; M. Malta, Tathiane; Wade, Taylor; S. Sabedot, Thaís; J. Brat, Daniel; V. Gould, Peter; Wöehrer, Adelheid; Aldape, Kenneth; Ismail, Azzam; Sivajothi, Santhosh; P Barthel, Floris; Kim, Hoon; Kocakavuk, Emre; Ahmed, Nazia; White, Kieron; Datta, Indrani; Moon, Hyo-Eun; Pollock, Steven; N. Goldfarb, Christine; Lee, Ga-Hyun; Garofano, Luciano; Anderson, Kevin; Nehar-Belaid, Djamel; S. Barnholtz‐Sloan, Jill; Bakas, Spyridon; T. Byrne, Annette; D’Angelo, Fulvio; K. Gan, Hui; Khasraw, Mustafa; Migliozzi, Simona; Ryan Ormond, D.; Ha Paek, Sun; G. Van Meir, Erwin; Walenkamp, Annemiek; Watts, Colin; Weiss, Tobias; Weller, Michael; Palucka, Karolina; F. Stead, Lucy; Poisson, Laila; Noushmehr, Houtan; Iavarone, Antonio; G.W. Verhaak, Roel; S. Varn, Frederick; C. Johnson, Kevin; Martinek, Jan; T. Huse, Jason; P. Nasrallah, MacLean; Wesseling, Pieter; Cooper, Lee; M. Malta, Tathiane; Wade, Taylor; S. Sabedot, Thaís; J. Brat, Daniel; V. Gould, Peter; Wöehrer, Adelheid; Aldape, Kenneth; Ismail, Azzam; Sivajothi, Santhosh; P Barthel, Floris; Kim, Hoon; Kocakavuk, Emre; Ahmed, Nazia; White, Kieron; Datta, Indrani; Moon, Hyo-Eun; Pollock, Steven; N. Goldfarb, Christine; Lee, Ga-Hyun; Garofano, Luciano; Anderson, Kevin; Nehar-Belaid, Djamel; S. Barnholtz‐Sloan, Jill; Bakas, Spyridon; T. Byrne, Annette; D’Angelo, Fulvio; K. Gan, Hui; Khasraw, Mustafa; Migliozzi, Simona; Ryan Ormond, D.; Ha Paek, Sun; G. Van Meir, Erwin; Walenkamp, Annemiek; Watts, Colin; Weiss, Tobias; Weller, Michael; Alfaro-Munoz, Kristin; B. Amin, Samirkumar; M. Ashley, David; Bock, Christoph; Brodbelt, Andrew; R. Bulsara, Ketan; Valéria Castro, Ana; Connelly, Jennifer; Costello, J; F. de Groot, John; Finocchiaro, Gaetano; J. French, Pim; Golebiewska, Anna; Hau, Ann‐Christin; Hong, Chibo; Horbinski, Craig; Kannan, Kasthuri; C.M. Kouwenhoven, Mathilde; Lasorella, Anna; S. LaViolette, Peter; L. Ligon, Keith; Lowman, Allison; Mehta, Shwetal; Miletić, Hrvoje; M. Molinaro, Annette; Ng, Ho‐Keung; P. Niclou, Simone; M. Niers, Johanna; J. Phillips, Joanna; Rabadán, Raúl; Rao, Ganesh; Reifenberger, Guido; Sanai, Nader; Short, Susan; Sillevis Smitt, Peter; E. Sloan, Andrew; Smits, Marion; M. Snyder, James; Suzuki, Hiromichi; Tabatabai, Ghazaleh; Tanner, Georgette; H. Tomaszewski, William; Wells, Michael; A. Westerman, Bart; Wheeler, Helen; Xie, Jichun; Alfred Yung, W.K.; Zadeh, Gelareh; Zhao, Junfei; Palucka, Karolina; F. Stead, Lucy; Poisson, Laila; Noushmehr, Houtan; Iavarone, Antonio; G.W. Verhaak, Roel

doi:10.1016/j.cell.2022.04.038

Public

Glioma progression is shaped by genetic evolution and microenvironment interactions

Published in Cell • May 31, 2022

Authors:

Frederick S. Varn

Kevin C. Johnson

Jan Martinek

Abstract

The factors driving therapy resistance in diffuse glioma remain poorly understood. To identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA sequencing data from the temporally separated tumor pairs of 304 adult patients with isocitrate dehydrogenase (IDH)-wild-type a...

Subject

Biology

Glioma

Tumor microenvironment

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