AI-based structure prediction empowers integrative structural analysis of human nuclear pores

Mosalaganti, Shyamal; Obarska-Kosińska, Agnieszka; Siggel, Marc; Taniguchi, Reiya; Turoňová, Beata; E. Zimmerli, Christian; Buczak, Katarzyna; H. Schmidt, Florian; Margiotta, Erica; Mackmull, Marie‐Therese; J. H. Hagen, Wim; Hummer, Gerhard; Kosiński, Jan; Beck, Martin

doi:10.1126/science.abm9506

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AI-based structure prediction empowers integrative structural analysis of human nuclear pores

Published in Science • Jun 9, 2022

Authors:

Shyamal Mosalaganti

Agnieszka Obarska-Kosińska

Marc Siggel

Abstract

INTRODUCTION The eukaryotic nucleus pro-tects the genome and is enclosed by the two membranes of the nuclear envelope. Nuclear pore complexes (NPCs) perforate the nuclear envelope to facilitate nucleocytoplasmic transport. With a molecular weight of ∼120 MDa, the human NPC is one of the larg-est pro...

Subject

Nuclear pore

Nucleoporin

Scaffold protein

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