AI-based structure prediction empowers integrative structural analysis of human nuclear pores

Mosalaganti, Shyamal; Obarska-Kosinska, Agnieszka; Siggel, Marc; Taniguchi, Reiya; Turoňová, Beata; E. Zimmerli, Christian; Buczak, Katarzyna; H. Schmidt, Florian; Margiotta, Erica; Mackmull, Marie-Therese; J. H. Hagen, Wim; Hummer, Gerhard; Kosinski, Jan; Beck, Martin

doi:10.1126/science.abm9506

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AI-based structure prediction empowers integrative structural analysis of human nuclear pores

Shared by NobleBlocks on Jun 10, 2022 • 12:00 AM UTC

Authors:

Shyamal Mosalaganti

Agnieszka Obarska-Kosinska

Marc Siggel

Abstract

INTRODUCTION The eukaryotic nucleus protects the genome and is enclosed by the two membranes of the nuclear envelope. Nuclear pore complexes (NPCs) perforate the nuclear envelope to facilitate nucleocytoplasmic transport. With a molecular weight of ∼120 MDa, the human NPC is one of the largest pro...

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