Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models

Sandra Chocron, E.; Munkácsy, Erin; S. Kim, Harper; Karpowicz, Przemyslaw; Jiang, Nisi; E. Van Skike, Candice; DeRosa, Nicholas; Q. Banh, Andy; P. Palavicini, Juan; Wityk, Paweł; Kalinowski, Leszek; Galvan, Veronica; A. Osmulski, Pawel; Jankowska, Elzbieta; Gaczynska, Maria; M. Pickering, Andrew

doi:10.1126/sciadv.abk2252

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Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models

Shared by NobleBlocks on Jun 10, 2022 • 12:00 AM UTC

Authors:

E. Sandra Chocron

Erin Munkácsy

Harper S. Kim

Abstract

The proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfun...

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