Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery

Zhou, Jun; Li, Maoyi; Chen, Qiufang; Li, Xinjie; Chen, Linfu; Dong, Ziliang; Zhu, Wenjun; Yang, Yang; Liu, Zhuang; Chen, Qian

doi:10.1038/s41467-022-31171-0

Public

Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery

Published in Nature Communications • Jun 14, 2022

Authors:

Jun Zhou

Maoyi Li

Qiufang Chen

Abstract

Abstract Reactive oxygen species (ROS) play vital roles in intestinal inflammation. Therefore, eliminating ROS in the inflammatory site by antioxidant enzymes such as catalase and superoxide dismutase may effectively curb inflammatory bowel disease (IBD). Here, Escherichia coli Nissle 1917 (ECN), a ...

Subject

Superoxide dismutase

Inflammation

Catalase

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