FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis

Guo, Dong; X. Lin, C.; Lu, Yuheng; Guan, Hong; Qi, Weizhong; Zhang, Hongbo; Zhang, Hongbo; Shao, Yan; Zeng, Chun; Zhang, Haiyan; Zhang, Haiyan; Zhang, Haiyan; Bai, Xiaochun; Cai, Daozhang

doi:10.1038/s41413-022-00211-2

Public

FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis

Published in Bone Research • Jun 22, 2022

Authors:

Dong Guo

C. X. Lin

Yuheng Lu

Abstract

Increasing evidence shows that adipokines play a vital role in the development of rheumatoid arthritis (RA). Fatty acid-binding protein 4 (FABP4), a novel adipokine that regulates inflammation and angiogenesis, has been extensively studied in a variety of organs and diseases. However, the effect of ...

Subject

Synovitis

Rheumatoid arthritis

Angiogenesis

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