Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus

Isidro, Joana; Borges, Vítor; Pinto, Miguel; Sobral, Daniel; Dourado Santos, João; Nunes, Alexandra; Mixão, Verónica; Ferreira, Rita; Santos, Daniela; Duarte, Sílvia; Vieira, Luı́s; José Borrego, Maria; Sofia Núncio, Maria; Lopes de Carvalho, Isabel; Pelerito, Ana; Cordeiro, Rita; Paulo Gomes, João

doi:10.1038/s41591-022-01907-y

Public

Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus

Published in Nature Medicine • Jun 24, 2022

Authors:

Joana Isidro

Vítor Borges

Miguel Pinto

Abstract

). In this study, shotgun metagenomics allowed the rapid reconstruction and phylogenomic characterization of the first MPXV outbreak genome sequences, showing that this MPXV belongs to clade 3 and that the outbreak most likely has a single origin. Although 2022 MPXV (lineage B.1) clustered with 2018...

Subject

Monkeypox

Microevolution

Clade

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