The<scp>PI3K</scp>/<scp>AKT</scp>signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities

He, Xuegang; Li, Ying; Deng, Bo; Lin, Aixin; Zhang, Guangzhi; Ma, Miao; Wang, Yonggang; Yang, Yong; Kang, Xuewen

doi:10.1111/cpr.13275

Public

ThePI3K/AKTsignalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities

Published in Cell Proliferation • Jun 26, 2022

Authors:

Xuegang He

Ying Li

Bo Deng

Abstract

OBJECTS: Traumatic spinal cord injury (TSCI) causes neurological dysfunction below the injured segment of the spinal cord, which significantly impacts the quality of life in affected patients. The phosphoinositide 3kinase/serine-threonine kinase (PI3K/AKT) signaling pathway offers a potential therap...

Subject

PI3K/AKT/mTOR pathway

Autophagy

Protein kinase B

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