Chemogenetic Disconnection between the Orbitofrontal Cortex and the Rostromedial Caudate Nucleus Disrupts Motivational Control of Goal-Directed Action

Oyama, Kei; Hori, Yukiko; Mimura, Koki; Nagai, Yuji; A. G. Eldridge, Mark; C. Saunders, Richard; Miyakawa, Naohisa; Hirabayashi, Toshiyuki; Hori, Yuki; Inoue, Ken‐ichi; Suhara, Tetsuya; Takada, Masahiko; Higuchi, Makoto; J. Richmond, Barry; Minamimoto, Takafumi

doi:10.1523/jneurosci.0229-22.2022

Public

Chemogenetic Disconnection between the Orbitofrontal Cortex and the Rostromedial Caudate Nucleus Disrupts Motivational Control of Goal-Directed Action

Published in Journal of Neuroscience • Jul 6, 2022

Authors:

Kei Oyama

Yukiko Hori

Koki Mimura

Abstract

The orbitofrontal cortex (OFC) and its major downstream target within the basal ganglia—the rostromedial caudate nucleus (rmCD)—are involved in reward-value processing and goal-directed behavior. However, a causal contribution of the pathway linking these two structures to goal-directed behavior has...

Subject

Orbitofrontal cortex

Neuroscience

Caudate nucleus

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