SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

J. Willett, Brian; Grove, Joe; A. MacLean, Oscar; Wilkie, Craig; De Lorenzo, Giuditta; Furnon, Wilhelm; Cantoni, Diego; Scott, Sam; Logan, Nicola; Ashraf, Shirin; Manali, Maria; Szemiel, Agnieszka; Cowton, Vanessa; Vink, Elen; T. Harvey, William; Davis, Chris; Asamaphan, Patawee; Smollett, Katherine; Tong, Lily; Orton, Richard; Hughes, Joseph; Holland, Poppy; Silva, Vanessa; J. Pascall, David; Puxty, Kathryn; da Silva Filipe, Ana; Yebra, Gonzalo; Shaaban, Sharif; T. G. Holden, Matthew; Maria Pinto, Rute; Gunson, Rory; Templeton, Kate; R. Murcia, Pablo; H. Patel, Arvind; Klenerman, Paul; Dunachie, Susanna; Consortium, PITCH; Dunachie, Susanna; Klenerman, Paul; Barnes, Eleanor; Brown, Anthony; Adele, Sandra; Kronsteiner, Barbara; M. Murray, Sam; Abraham, Priyanka; Deeks, Alexandra; Azim Ansari, M.; de Silva, Thushan; Turtle, Lance; Moore, Shona; Austin, James; Richter, Alex; Duncan, Christopher; Payne, Rebecca; COVID-19 Genomics UK (COG-UK) Consortium, The; Ash, Amy; Koshy, Cherian; Kele, Beatrix; Cutino-Moguel, Teresa; J. Fairley, Derek; P. McKenna, James; Curran, Tanya; Adams, Helen; Fraser, Christophe; Bonsall, David; Fryer, Helen; Lythgoe, Katrina; Thomson, Laura; Golubchik, Tanya; Murray, Abigail; Singleton, Dawn; M. Beckwith, Shaun; Mantzouratou, Anna; Barrow, Magdalena; L. Buchan, Sarah; Reynolds, Nicola; Warne, Ben; Maksimovic, Joshua; Spellman, Karla; McCluggage, Kathryn; John, Michaela; Beer, Robert; Afifi, Safiah; Morgan, Sian; Mack, Andrew; Marchbank, Angela; Price, Anna; Morriss, Arthur; Bresner, Catherine; Kitchen, Christine; Merrick, Ian; Southgate, Joel; Guest, Martyn; Jones, Owen; Munn, Robert; R. Connor, Thomas; Whalley, Thomas; Workman, Trudy; Fuller, William; Patel, Amita; Patel, Bindi; Nebbia, Gaia; Edgeworth, Jonathan; B. Snell, Luke; Batra, Rahul; Charalampous, Themoula; H. Beckett, Angela; Shelest, Ekaterina; C. Robson, Samuel; P. Underwood, Anthony; E. W. Taylor, Ben; A. Yeats, Corin; M. Aanensen, David; Abudahab, Khalil; Menegazzo, Mirko; Joseph, Amelia; Clark, Gemma; C. Howson-Wells, Hannah; Berry, Louise; Khakh, Manjinder; M. Lister, Michelle; Boswell, Tim; M. Fleming, Vicki; W. Holmes, Christopher; L. McMurray, Claire; Shaw, Jessica; W. Tang, Julian; Fallon, Karlie; Odedra, Mina; J. Willford, Nicholas; W. Bird, Paul; Helmer, Thomas; Williams, Lesley-Anne; Sheriff, Nicola; Campbell, Sharon; Raviprakash, Veena; Blakey, Victoria; Moore, Christopher; Sang, Fei; Debebe, Johnny; Carlile, Matthew; W. Loose, Matthew; Holmes, Nadine; Wright, Victoria; Estee Torok, M.; L. Hamilton, William; M. Carabelli, Alessandro; Jermy, Andrew; Blane, Beth; M. Churcher, Carol; Ludden, Catherine; Aggarwal, Dinesh; Westwick, Elaine; Brooks, Ellena; M. McManus, Georgina; Galai, Katerina; Smith, Ken; S. Smith, Kim; Cox, MacGregor; Fragakis, Mireille; Maxwell, Patrick; Judges, Sarah; J. Peacock, Sharon; Feltwell, Theresa; Kenyon, Anita; Eldirdiri, Sahar; Davis, Thomas; F. Taylor, Joshua; Keong Tan, Ngee; E. Zarebski, Alex; Gutierrez, Bernardo; Raghwani, Jayna; du Plessis, Louis; U. G. Kraemer, Moritz; G. Pybus, Oliver; Francois, Sarah; W. Attwood, Stephen; I. Vasylyeva, Tetyana; S. Jahun, Aminu; G. Goodfellow, Ian; Georgana, Iliana; L. Pinckert, Malte; Hosmillo, Myra; Izuagbe, Rhys; Chaudhry, Yasmin; Ryan, Felicity; Lowe, Hannah; Moses, Samuel; Bedford, Luke; S. Cargill, James; Hughes, Warwick; Moore, Jonathan; Stonehouse, Susanne; Shah, Divya; C. D. Lee, Jack; R. Brown, Julianne; A. Harris, Kathryn; Atkinson, Laura; Storey, Nathaniel; J. Spyer, Moira

doi:10.1038/s41564-022-01143-7

Public

SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Shared by NobleBlocks on Jul 7, 2022 • 12:00 AM UTC

Authors:

Brian J. Willett

Joe Grove

Oscar A. MacLean

Abstract

Abstract Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone of the public health response to COVID-19. The emergence of hypermutated, increasingly transmissible variants of concern (VOCs) threaten this strategy. Omicron (B.1.1.529), the fifth VOC to be described, harbours multiple a...

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