Assessment of the Intestinal Absorption of Higher Olefins by the Everted Gut Sac Model in Combination with In Silico New Approach Methodologies

Shi, Quan; Carrillo, Juan-Carlos; G. Penman, Michael; Manton, Jason; Fioravanzo, Elena; H. Powrie, Robert; R. Elcombe, Clifford; Borsboom-Patel, Tilly; Tian, Yuan; Shen, Hua; J. Boogaard, Peter

doi:10.1021/acs.chemrestox.2c00089

Public

Assessment of the Intestinal Absorption of Higher Olefins by the Everted Gut Sac Model in Combination with In Silico New Approach Methodologies

Published in Chemical Research in Toxicology • Jul 13, 2022

Authors:

Quan Shi

Juan-Carlos Carrillo

Michael G. Penman

Abstract

To reduce the number of animals and studies needed to fulfill the information requirements as required by Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) (EC no. 1907/2006), a read-across approach was used to support approximately 30 higher olefins. This study aimed to a...

Subject

Lipophilicity

In silico

Reactivity (psychology)

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