The Knock-Down of the Chloroquine Resistance Transporter PfCRT Is Linked to Oligopeptide Handling in Plasmodium falciparum

P. Sanchez, Cecília; Manson, Erin; Moliner Cubel, Sonia; Mandel, Luis; Weidt, Stefan; P. Barrett, Michael; Lanzer, Michael

doi:10.1128/spectrum.01101-22

Public

The Knock-Down of the Chloroquine Resistance Transporter PfCRT Is Linked to Oligopeptide Handling in Plasmodium falciparum

Published in Microbiology Spectrum • Jul 18, 2022

Authors:

Cecília P. Sanchez

Erin Manson

Sonia Moliner Cubel

Abstract

The chloroquine resistance transporter, PfCRT, is important for the survival of the human malaria parasite Plasmodium falciparum. It increases the tolerance to many antimalarial drugs, and it is essential for the development of the parasite within red blood cells. While we understand the role of PfC...

Subject

Plasmodium falciparum

Oligopeptide

Chloroquine

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