Cytochrome P450<sub>Blt</sub>Enables Versatile Peptide Cyclisation to Generate Histidine‐ and Tyrosine‐Containing Crosslinked Tripeptide Building Blocks

Zhao, Yongwei; Marschall, Edward; Treisman, Maxine; I. McKay, Alasdair; Padva, Leo; Crüsemann, Max; R. Nelson, David; L. Steer, David; B. Schittenhelm, Ralf; Tailhades, Julien; J. Cryle, Max

doi:10.1002/anie.202204957

Public

Cytochrome P450BltEnables Versatile Peptide Cyclisation to Generate Histidine‐ and Tyrosine‐Containing Crosslinked Tripeptide Building Blocks

Published in Angewandte Chemie International Edition • Jul 19, 2022

Authors:

Yongwei Zhao

Edward Marschall

Maxine Treisman

Abstract

We report our investigation of the utility of peptide crosslinking cytochrome P450 enzymes from biarylitide biosynthesis to generate a range of cyclic tripeptides from simple synthons. The crosslinked tripeptides produced by this P450 include both tyrosine-histidine (A-N-B) and tyrosine-tryptophan (...

Subject

Tripeptide

Tyrosine

Peptide

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