The Serotonin Theory of Depression: A Systematic Umbrella Review of the Evidence

Moncrieff, Joanna; Cooper, Ruth; Stockmann, Tom; Amendola, Simone; P. Hengartner, Michael; Horowitz, Mark

doi:10.1038/s41380-022-01661-0

Public

The Serotonin Theory of Depression: A Systematic Umbrella Review of the Evidence

Published in Molecular Psychiatry • Jul 20, 2022

Authors:

Joanna Moncrieff

Ruth Cooper

Tom Stockmann

Abstract

Abstract The serotonin hypothesis of depression is still influential. We aimed to synthesise and evaluate evidence on whether depression is associated with lowered serotonin concentration or activity in a systematic umbrella review of the principal relevant areas of research. PubMed, EMBASE and Psyc...

Subject

Serotonin transporter

Meta-analysis

PsycINFO

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