Gut Microbially Produced Indole-3-Propionic Acid Inhibits Atherosclerosis by Promoting Reverse Cholesterol Transport and Its Deficiency Is Causally Related to Atherosclerotic Cardiovascular Disease

Xue, Hongliang; Chen, Xu; Yu, Chao; Deng, Yuqing; Zhang, Yuan; Shen, Chen; Chen, Xuechen; Chen, Ke; Yang, Yan; Ling, Wenhua

doi:10.1161/circresaha.122.321253

Public

Gut Microbially Produced Indole-3-Propionic Acid Inhibits Atherosclerosis by Promoting Reverse Cholesterol Transport and Its Deficiency Is Causally Related to Atherosclerotic Cardiovascular Disease

Published in Circulation Research • Jul 27, 2022

Authors:

Hongliang Xue

Xu Chen

Chao Yu

Abstract

Background: Accumulating evidence has shown that disorders in the gut microbiota and derived metabolites affect the development of atherosclerotic cardiovascular disease (ASCVD). However, which and how specific gut microbial metabolites contribute to the progression of atherosclerosis and the clinic...

Subject

Reverse cholesterol transport

Disease

Cholesterol

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