Effect of High- vs Low-Dose Tranexamic Acid Infusion on Need for Red Blood Cell Transfusion and Adverse Events in Patients Undergoing Cardiac Surgery

Shi, Jia; Zhou, Chenghui; Pan, Wei; Sun, Hansong; Liu, Sheng; Feng, Wei; Wang, Weijian; Cheng, Zhaoyun; Wang, Yang; Zheng, Zhe; Study Group, OPTIMAL; Wang, Liqing; Song, Yunhu; Yu, Chuntao; Wang, Xin; Wang, Xianqiang; Fan, Hongguang; Yang, Yan; Xu, Fei; Gao, Ge; Zhang, Yan; Li, Haojie; Li, Wei; Li, Jing; Yan, Fuxia; Yuan, Su; Zhao, Yan; Zhang, Yue; Ji, Bingyang; Zhang, Heng; Liu, Jiamin; Ma, Yan; Du, Juan; Chen, Zujun; Shi, Li; Fan, Yuxiu; Lin, Hongqi; Wang, Taofu; Lu, Ting; Dai, Zheng; Xie, Chunmei

doi:10.1001/jama.2022.10725

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Effect of High- vs Low-Dose Tranexamic Acid Infusion on Need for Red Blood Cell Transfusion and Adverse Events in Patients Undergoing Cardiac Surgery

Shared by NobleBlocks on Jul 26, 2022 • 12:00 AM UTC

Authors:

Jia Shi

Chenghui Zhou

Wei Pan

Abstract

Importance Tranexamic acid is recommended for reducing blood loss and transfusion in cardiac surgery. However, it remains unknown whether a high dose of tranexamic acid provides better blood-sparing effect than a low dose without increasing the risk of thrombotic complications or seizures in cardiac...

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