Combination Therapy Comprising Paclitaxel and 5-Fluorouracil by Using Folic Acid Functionalized Bovine Milk Exosomes Improves the Therapeutic Efficacy against Breast Cancer

Naveen Kumar, Dulla; Chaudhuri, Aiswarya; Dehari, Deepa; Shekher, Anusmita; C. Gupta, Subash; Majumdar, Shreyasi; Krishnamurthy, Sairam; Singh, Sanjay; Kumar, Dinesh; Kumar Agrawal, Ashish

doi:10.3390/life12081143

Public

Combination Therapy Comprising Paclitaxel and 5-Fluorouracil by Using Folic Acid Functionalized Bovine Milk Exosomes Improves the Therapeutic Efficacy against Breast Cancer

Published in Life • Jul 28, 2022

Authors:

Dulla Naveen Kumar

Aiswarya Chaudhuri

Deepa Dehari

Abstract

Paclitaxel (PAC) has been approved by FDA for clinical use (Taxol®), yet dose-dependent severe toxicity due to the adjuvant Cremophor EL® in combination with ethanol is a major drawback. The drawbacks of the current therapy can be overcome by (i) finding a suitable vehicle that cannot only bypass th...

Subject

Paclitaxel

Folic acid

Microvesicles

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