Intracavity generation of glioma stem cell–specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy

Chen, Chen; Jing, Weiqiang; Chen, Yu; Wang, Ganyu; Abdalla, Mohnad; Gao, Lin; Han, Maosen; Shi, Chongdeng; Li, Anning; Sun, Peng; Jiang, Xin; Yang, Zhenmei; Zhang, Shengchang; Zhang, Jing; Tang, Chunwei; Liu, Ying; Zhang, Rui; Xu, Fengbo; Dong, Baixiang; Li, Xueen; Liu, Minglu; Qiang, Bangming; Sun, Yanhua; Wei, Xia; Li, Jun; Hu, Quanyin; Jiang, Xinyi

doi:10.1126/scitranslmed.abn1128

Public

Intracavity generation of glioma stem cell–specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy

Shared by NobleBlocks on Aug 3, 2022 • 12:00 AM UTC

Authors:

Chen Chen

Weiqiang Jing

Yu Chen

Abstract

Glioblastoma multiforme (GBM) remains incurable despite aggressive implementation of multimodal treatments after surgical debulking. Almost all patients with GBM relapse within a narrow margin around the initial resected lesion due to postsurgery residual glioma stem cells (GSCs). Tracking and eradi...

Discussions