A single-cell atlas of the multicellular ecosystem of primary and metastatic hepatocellular carcinoma

Lu, Yiming; Yang, Aiqing; Quan, Cheng; Pan, Yingwei; Zhang, Haoyun; Li, Yuanfeng; Gao, Chengming; Lu, Hao; Wang, Xueting; Cao, Pengbo; Chen, Hongxia; Lu, Shichun; Zhou, Gangqiao

doi:10.1038/s41467-022-32283-3

Public

A single-cell atlas of the multicellular ecosystem of primary and metastatic hepatocellular carcinoma

Published in Nature Communications • Aug 6, 2022

Authors:

Yiming Lu

Aiqing Yang

Cheng Quan

Abstract

Abstract Hepatocellular carcinoma (HCC) represents a paradigm of the relation between tumor microenvironment (TME) and tumor development. Here, we generate a single-cell atlas of the multicellular ecosystem of HCC from four tissue sites. We show the enrichment of central memory T cells (T CM ) in th...

Subject

Tumor microenvironment

Hepatocellular carcinoma

Cancer research

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