The transcription factor E2F1 controls the GLP-1 receptor pathway in pancreatic β cells

Bourouh, Cyril; Courty, Émilie; Rolland, Laure; Pasquetti, Gianni; Gromada, Xavier; Rabhi, Nabil; Carney, Charlène; Moreno, Maeva; Boutry, Raphaël; Caron, Émilie; Benfodda, Zohra; Meffre, Patrick; Kerr‐Conte, Julie; Pattou, François; Froguel, Philippe; Bonnefond, Amélie; Oger, Frédérik; Annicotte, Jean‐Sébastien

doi:10.1016/j.celrep.2022.111170

Public

The transcription factor E2F1 controls the GLP-1 receptor pathway in pancreatic β cells

Published in Cell Reports • Aug 1, 2022

Authors:

Cyril Bourouh

Émilie Courty

Laure Rolland

Abstract

The glucagon-like peptide 1 (Glp-1) has emerged as a hormone with broad pharmacological potential in type 2 diabetes (T2D) treatment, notably by improving β cell functions. The cell-cycle regulator and transcription factor E2f1 is involved in glucose homeostasis by modulating β cell mass and functio...

Subject

E2F1

Glucose homeostasis

Endocrinology

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