Effect of Intravenous Tirofiban vs Placebo Before Endovascular Thrombectomy on Functional Outcomes in Large Vessel Occlusion Stroke

BT Trial Investigators, RESCUE; Shuai, Jie; Gong, Zili; Huang, Li; Liu, Juan; Tang, Kun; Duan, Zhenhui; Ni, Houjie; Liu, Yumin; Xie, Fei; Yan, Dongrun; Ye, Songsheng; Zhang, Zhiquan; Cao, Zhihua; Shang, Xianjin; Ding, Xianhui; Xu, Xiangjun; Chen, Li; Wu, Jiachuan; Meng, Renliang; Jiang, Li; Xie, Yang; Lei, Lei; Zhao, Libo; Yu, Tao; Luo, Zhengjin; Ли, Бин; Wang, Ning; Sun, Jun; Liang, Yong; Li, Zongqin; Xue-jie, XU; Song, Kangjia; Hao, Zeyu; Yu, Chuanqing; Zhou, Xiaofei; Zuo, Jing; Wu, Wenbin; Chen, Xiyang; Tian, Yaoyu; Hu, Xiaogang; Liang, Wei; Wu, Xiuhua; Fu, Dezheng; Han, Ce; Li, Chunying; Liu, Yachun; Xu, Chukai; Deng, Shiyu; Fang, Ling; Gu, Gangfeng; Su, Rong; Guo, Jing; Wang, Jing; Cao, Minghua; Wu, Mingchao; Wu, Xuxu; Wu, Yu‐Peng; Qi, Jisheng; Liu, Da; Long, Wenkai; Zhang, Yuxian; Tang, Mingshan; Zeng, Fei; Liu, Changya; Tang, Tieyu; Yang, Ying; Zhou, Yongliang; Xue, Dongzhang; Han, Ju; Wang, Jianhong; Liu, Xuan; Zheng, Xu; Xu, Anding; Zhang, Guilian; Dong, Yi; Hao, Yonggang; Liu, Dan; Lin, Min; Lv, Fajin; Qin, Chao; Yang, Hua; Qiu, Zhongming; Li, Fengli; Sang, Hongfei; Luo, Weidong; Liu, Shuai; Liu, Wenhua; Guo, Zhangbao; Li, Huagang; Sun, Dong; Huang, Wenguo; Zhang, Min; Zhang, Min; Dai, Weipeng; Zhou, Peiyang; Deng, Wei; Zhou, Zhiming; Huang, Xianjun; Lei, Bo; Li, Jinglun; Yuan, Zhengzhou; Song, Bo; Miao, Jian; Liu, Shudong; Jin, Zhenglong; Zeng, Guoyong; Zeng, Hongliang; Yuan, Junjie; Wen, Changming; Yu, Yang; Yuan, Guangxiong; Wu, Junxiong; Chen, Long; Luo, Jun; Tian, Zhenxuan; Zheng, Chong; Hu, Zhizhou; Wang, Shouchun; Wang, Tao; Li, Qi; Li, Rongzong; Wan, Yue; Ke, Yingbing; Wu, Youlin; Zhu, Xiurong; Kong, Weilin; Huang, Jiacheng; Peng, Daizhou; Chang, Mingze; Ge, Hanming; Shi, Zhonghua; Yan, Zhizhong; Du, Jie; Jin, Ying; Ju, Dongsheng; Huang, Chuming; Hong, Yifan; Liu, Tianzhu; Zhao, Wenlong; Wang, Jian; Zheng, Bo; Wang, Li; Liu, Shugai; Luo, Xiao‐Jun; Luo, Shiwei; Xu, Xinwei; Hu, Jinrong; Pu, Jie; Chen, Shengli; Sun, Yaxuan; Jiang, Shunfu; Wei, Liping; Fu, Xinmin; Bai, Yongjie; Yang, Shunyu; Hu, Wei; Zhang, Guling; Pan, Chengde; Zhang, Shuai; Wang, Yan; Cao, Wenfeng; Yang, Shiquan; Zhang, Jun; Guo, Fuqiang; Wen, Hongbin; Zhang, Jinhua; Song, Jiaxing; Yue, Chengsong; Li, Linyu; Wu, Deping; Tian, Yan; Yang, Jie; Lu, Mengjie; L. Saver, Jeffrey; G. Nogueira, Raul; Zi, Wenjie; Yang, Qingwu

doi:10.1001/jama.2022.12584

Public

Effect of Intravenous Tirofiban vs Placebo Before Endovascular Thrombectomy on Functional Outcomes in Large Vessel Occlusion Stroke

Published in JAMA • Aug 9, 2022

Authors:

RESCUE BT Trial Investigators

Jie Shuai

Zili Gong

Abstract

Importance: Tirofiban is a highly selective nonpeptide antagonist of glycoprotein IIb/IIIa receptor, which reversibly inhibits platelet aggregation. It remains uncertain whether intravenous tirofiban is effective to improve functional outcomes for patients with large vessel occlusion ischemic stroke...

Subject

Tirofiban

Medicine

Modified Rankin Scale

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