Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: Biological role in induction, regulation, and treatment

Amarachi Ihim, Stella; Dahiru Abubakar, Sharafudeen; Zian, Zeineb; Sasaki, Takanori; Saffarioun, Mohammad; Maleknia, Shayan; Azizi, Gholamreza

doi:10.3389/fimmu.2022.919973

Public

Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: Biological role in induction, regulation, and treatment

Published in Frontiers in Immunology • Aug 11, 2022

Authors:

Stella Amarachi Ihim

Sharafudeen Dahiru Abubakar

Zeineb Zian

Abstract

Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine involved in host defense against infections and regulates the innate and acquired immune response. IL-18 is produced by both hematopoietic and non-hematopoietic cells, including monocytes, macrophages, keratinocytes and mesenchymal cell. I...

Subject

Immunology

Medicine

Immune system

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