Ancestral Sequence Reconstruction Identifies Structural Changes Underlying the Evolution of <i>Ideonella sakaiensis</i> PETase and Variants with Improved Stability and Activity

Joho, Yvonne; Vongsouthi, Vanessa; A. Spence, Matthew; Ton, Jennifer; Gomez, Chloe; Lynn Tan, Li; A. Kaczmarski, Joe; T. Caputo, Alessandro; Royan, Santana; J. Jackson, Colin; Ardèvol, Albert

doi:10.1021/acs.biochem.2c00323

Public

Ancestral Sequence Reconstruction Identifies Structural Changes Underlying the Evolution of Ideonella sakaiensis PETase and Variants with Improved Stability and Activity

Published in Biochemistry • Aug 11, 2022

Authors:

Yvonne Joho

Vanessa Vongsouthi

Matthew A. Spence

Abstract

The improved production, recycling, and removal of plastic waste, such as polyethylene terephthalate (PET), are pressing environmental and economic issues for society. Biocatalytic (enzymatic) PET depolymerization is potentially a sustainable, low-energy solution to PET recycling, especially when co...

Subject

Depolymerization

Polyethylene terephthalate

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