Infant BCG vaccination and risk of pulmonary and extrapulmonary tuberculosis throughout the life course: a systematic review and individual participant data meta-analysis

Martínez, Leonardo; Cords, Olivia; Liu, Qiao; Acuña-Villaorduña, Carlos; Bonnet, Maryline; J. Fox, Greg; Cristina Calçada Carvalho, Anna; Chan, Pei‐Chun; Croda, Júlio; C. Hill, Philip; López‐Varela, Elisa; Donkor, Simon; Fielding, Katherine; Graham, Hamish; Espinal, Marcos; Kampmann, Beate; Reingold, Arthur; Huerga, Helena; A. Villalba, Julian; Grandjean, Louis; Sotgiu, Giovanni; Egere, Uzochukwu; Singh, Sarman; Zhu, Limei; Lienhardt, Christian; T. Denholm, Justin; A. Seddon, James; C. Whalen, Christopher; L. García‐Basteiro, Alberto; Triasih, Rina; Chen, Cheng; Singh, Jitendra; Huang, Li‐Min; K. Sharma, Surendra; Hannoun, Djohar; del Corral, Helena; M. Mandalakas, Anna; L. Malone, LaShaunda; Ling, Du-Lin; Lineu Kritski, Afrânio; M. Stein, Catherine; Vashishtha, Richa; Boulahbal, F; Fang, Chi‐Tai; Henry Boom, W.; Martins Netto, Eduardo; Carlos Moreira Lemos, Antônio; C. Hesseling, Anneke; Kay, Alexander; C. Jones‐López, Edward; Robert Horsburgh, C.; Lange, Christoph; R. Andrews, Jason

doi:10.1016/s2214-109x(22)00283-2

Public

Infant BCG vaccination and risk of pulmonary and extrapulmonary tuberculosis throughout the life course: a systematic review and individual participant data meta-analysis

Published in The Lancet Global Health • Aug 9, 2022

Authors:

Leonardo Martínez

Olivia Cords

Qiao Liu

Abstract

BACKGROUND: BCG vaccines are given to more than 100 million children every year, but there is considerable debate regarding the effectiveness of BCG vaccination in preventing tuberculosis and death, particularly among older children and adults. We therefore aimed to investigate the age-specific impa...

Subject

Medicine

Tuberculosis

Vaccination

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