ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage

Ma, Xiaohui; Liu, Jiang-Han-Zi; Liu, Chunyu; Sun, Wan‐Yang; Duan, Wen‐Jun; Wang, Guan; Kurihara, Hiroshi; He, Rong‐Rong; Li, Yi-Fang; Chen, Yang; Shang, Hongcai

doi:10.1038/s41392-022-01090-z

Public

ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage

Published in Signal Transduction and Targeted Therapy • Aug 15, 2022

Authors:

Xiaohui Ma

Jiang-Han-Zi Liu

Chunyu Liu

Abstract

Myocardial ischemia/reperfusion (I/R) injury is a classic type of cardiovascular disease characterized by injury to cardiomyocytes leading to various forms of cell death. It is believed that irreversible myocardial damage resulted from I/R occurs due to oxidative stress evoked during the reperfusion...

Subject

Lipid peroxidation

Ischemia

Arachidonic acid

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